On the Role of Ribonucleic Acid in Animal Virus Synthesis

Ribonucleic Acids in Virus-infected and Uninfected Krebs Ii Ascites Tumor Cells.

Two lines of evidence support the view that the replication of ribonucleic acid-containing animal viruses proceeds via RNAdirected synthesis of RNA. It has been shown that RNA viruses continue to replicate under conditions in which synthesis of deoxyribonucleic acid and the DNB-dependent synthesis of RNA are artificially suppressed (l-3). Furthermore, in certain mammalian cell lines there is ev...

Inhibition of early vaccinia virus ribonucleic acid synthesis in interferon-treated chicken embryo fibroblasts.

Pretreatment of chicken embryo cells with homologous but not heterologous interferon inhibits the synthesis of vaccinia virus early messenger ribonucleic acid (mRNA). This inhibition is seen in the presence of cycloheximide, i.e., in the absence of protein synthesis, suggesting that the virion-bound transcriptase may be the target of the antiviral activity associated with interferon treatment. ...

Inhibition of Ribonucleic Acid Synthesis in Newcastle Disease Virus-infected Cells by Puromycin and 6-azauridine.

Wilson, D. E. (Rensselaer Polytechnic Institute, Troy, N.Y.), and P. LoGerfo. Inhibition of ribonucleic acid synthesis in Newcastle disease virus-infected cells by puromycin and 6-azauridine. J. Bacteriol. 88:1550-1555. 1964.-Puromycin and 6-azauridine were used to inhibit protein and ribonucleic acid (RNA) synthesis during Newcastle disease virus replication. Viral RNA, measured by the incorpo...

Inhibition of Certain Deoxyribonucleic Acid

A proteinaceous substance was detected in the liver of several animal species that inhibited the multiplication of certain deoxyribonucleic acid, but not ribonucleic acid, viruses. Preliminary experiments suggested that its site of action was not extracellular. It did not inhibit virus by interfering with adsorption to cells. It was suggested that this inhibiting substance acts directly upon ce...

Indirect evidence for the presence of Ribonucleic acid in vesicular stomatitis Virions